Scientist, Medicinal Chemistry

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Position Summary

POINT Biopharma, a wholly owned subsidiary of Eli Lilly, is looking for a Scientist, Medicinal Chemistry to join our Discovery and Preclinical R&D team. The successful candidate will have a strong background in small molecule and peptide synthesis and will leverage these skills to advance new ligands for targeted radiopharmaceuticals. A strong understanding in drug discovery, microbiology/biochemistry assay analysis, analytical chemistry, and animal model DMPK is also important. This position is an onsite role in our Discovery lab located in Toronto, Ontario.

Responsibilities

• Support early targeted radiopharmaceuticals drug discovery efforts.
• Independently plan and carry out the synthesis, purification, and characterization of target molecules, including small molecule ligands and oligopeptides.
• Perform routine maintenance on laboratory equipment.
• Coordinating and collaborating with external (CRO’s) and internal groups across CMC, preclinical, DMPK, etc.
• Participate in study design, vendor selection, study execution, interpretation and report writing.
• Facilitate preparation, packaging, and shipping of materials to other facilities and external partners.
• Work with chemists and logistics teams to source, purchase, and monitor ships of commercial chemicals.
• Generate and manage internal documentation involve chemical structure and characterization databases.
• Work collaboratively with teams of diverse scientific expertise and clearly communicate experimental details and scientific results.
• Demonstrate flexibility in day-to-day operations, assisting other divisions in R&D.
  
  
  

Basic Requirements

• MS or PhD in organic chemistry, medicinal chemistry, or related fields.
• 2+ years relevant post-graduate experience in synthetic chemistry.
• Experience with small molecule organic synthesis and design of reactions
• Experience in normal and reverse phase chromatography.
• Ability to analyze composition and purity of products (NMR, HPLC, MS).
• Experience with multi-step organic synthesis and characterization w/ working knowledge of solid-phase peptide synthesis.
• Understanding of medicinal chemistry, microbiology, biochemistry, and PK/PD principles.
• Capable of working independently and managing time effectively.
• Excellent problem solving and decision-making skills.
• Excellent oral and written communication skills, with the ability communicate scientific results to an interdisciplinary team.
  
  
  

Additional Preferences

• Working knowledge of MS-Office, ChemDraw, MestreNova.
  
  
  

Additional Information

Physical Demands/Travel:

The physical demands of this job are consistent with a lab environment.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in a Laboratory.

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

• To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
  
  
  

Eli Lilly Canada is committed to employment equity. We encourage applications from qualified women, members of visible minorities, aboriginal peoples, and persons with disabilities.

Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( [email protected] ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

Lilly does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( [email protected] ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

Lilly does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

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