Principal Immunoengineer – Protein Design & Immunogenicity (Large Molecule Discovery)

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Principal Immunoengineer – Protein Design & Immunogenicity (Large Molecule Discovery)

What you will do

Let’s do this. Let’s change the world. We have an opening for a Principal Scientist on our Large Molecule Discovery group, located at Amgen British Columbia. Our team specializes in the discovery of large molecules and the development of Predictive In vitro Biological Systems to evaluate the efficacy and safety of new candidate molecules.

You will lead translational efforts in protein design with a mission to eliminate or reduce immunogenicity in large molecule therapeutics. This pivotal role bridges experimental immunology and computational science to ensure novel biologics are safe and effective from the outset.

What your role will be

• To embed with our wet-lab teams and lead communication and drive collaboration between the computational data sciences and laboratory research teams.
• Leverage ground-breaking technologies to interrogate adaptive humoral and cellular immune responses
• Design experiments to test and validate novel immunomodulatory methods and compounds
• Develop strategies to direct the adaptive immune response towards desired outcomes
• Collaborate with protein engineers to create, test and optimize novel molecule designs
• Lead external collaborations with academic and industry partners to access emerging technologies in Immunoengineering and AI-driven protein design.
• Monitor and evaluate scientific advances relevant to adaptive immunity and therapeutic engineering to inform strategic R&D decisions.

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The professional we seek is an innovative leader with these qualifications.

Basic Qualifications:

Doctorate degree and 6 years of relevant experience

Or

Master’s degree and 10 years of relevant experience

Or

Bachelor’s degree and 12 years of relevant experience

And

4 years of managerial experience directly managing people and/or leadership experience leading teams, projects, programs or directing the allocation of resources

Preferred Qualifications:

• PhD in Immunology, Biomedical Engineering, Vaccinology or Computational Systems Biology.
• Postdoctoral studies in related disciplines; antigen-processing, vaccine design, T and B cell epitope prediction, immune repertoire profiling.
• Hands-on experience with in vitro immunogenicity assays and in silico modeling tools
• Proven track record of integrating laboratory science and state-of-the-art machine learning protein design modeling tools to solve challenging protein design problems
• Experience working in the wet lab or directly with wet lab scientists
• Great communication abilities and meticulous attention to detail, including for written and oral presentation and code documentation
• Broad general interest in modeling complex biological systems
• Ability to drive an end-to-end project including working with collaborators to deliver results
• Desire to be part of a team that transforms objectives into tangible outcomes, propels numerous dynamic projects, and cultivates effective cross-functional partnerships

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

Amgen is proud to have been recognized as one of LinkedIn Top 25 Companies in Canada for career growth. Click HERE for more details.

The base salary range for this position in Canada is $145,765 - $169,846 CAD.

In addition to the base salary, Amgen offers competitive and comprehensive Total Rewards Plans that are aligned with local industry standards.

Apply now and make a lasting impact with the Amgen team.

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As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.