Scientist, Radiochemistry

Scientist, Radiochemistry About Us

Alpha-9 Oncology is a clinical-stage biotechnology company developing radiopharmaceuticals for solid and hematologic malignancies. Alpha-9 has a portfolio of molecules entering clinical trials and a robust pipeline of additional targets for future development. With a strong cash position, raised from leading healthcare investors, Alpha-9 is poised to dramatically expand its team and accelerate its pipeline.

Radiopharmaceuticals, which enable internal delivery of radiation directly to tumor sites, are emerging as an exciting new class of cancer drugs. The field has evolved dramatically in the last few years, attributable to scientific advances and recent product launches. Radiopharmaceuticals are unique in that the same molecule can be used for imaging or therapeutic purposes, allowing doctors to visualize the molecule in patients prior to administration of therapy. The drug development cycle is also much shorter and capital efficient than traditional modalities.

Position Summary

Alpha-9 Oncology is seeking a Scientist, Radiochemistry to join our growing team. The ideal candidate will have extensive hands-on experience with radiolabeling using various isotopes (e.g., 177 Lu, 225 Ac, 68 Ga), and analytical techniques to confirm yields, (radio)purity and stability to support in vitro/vivo and formulation evaluations. The ideal candidate will have multi-tasking ability, be able to function independently/within a team, and a desire to strive in a fast-paced, highly collaborative environment.

Some specific duties and tasks include, but are not limited to, the following:

• Independently apply radiolabelling methods to enable preclinical evaluation for compounds with imaging and therapeutic applications.
• Design and execution of radiochemistry experiments leading to robust radiolabelling processes.
• Development of analytical methods, notably those involving radioactivity (e.g., radio-TLC, radio-HPLC).
• Active participation in discussions and presentation of results in team meetings
• Diligent, clear and accurate recording of experiment procedures/outcomes. Ability to collate results to data packages, when appropriate.
• Supervise and mentor Associate Scientists.
• Support of lab maintenance and upkeep (e.g., routine instrument care, inventory management)
• Firm adherence to all safety and compliance requirements, including radiation surveys, contamination control, and radioactive inventory/waste management.
  
  

Qualifications

• Ph.D/M.Sc degree in Radiochemistry, Chemistry, Analytical Chemistry or related area with 1-4 years (with Ph.D) or 5 years (with M.Sc) of related industrial experience.
• Ability to understand, plan and execute (with practical experience) radiolabeling experiments and subsequent analysis. Experience with both Alpha and PET emitters preferred.
• Demonstrated ability to troubleshoot, identify unusual results and design experiments to establish root cause.
• Excellent observational, organizational, data management, and documentation skills
• Strong written and oral communication skills.
• A team player with excellent interpersonal skills and a strong passion for the discovery of targeted imaging/therapy in a fast-paced start-up environment.
  
  

What’s In It For You

• Full extended health and dental benefits
• Competitive Salary, Bonus, and Equity
• Commuter Reimbursement
• Group Registered Retirement Savings Plan with 5% employer match
• 20 vacation days
• 17 Holidays
• 5 Sick Days
• Long Term Disability
• Life Insurance
• Technology allowance
• Impactful rewarding work
  
  

Location: Vancouver, British Columbia, Canada